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Leflunomide (Arava)
Available:
10 mg, 20 mg, and 100 mg tablets
Dose: 10
to 20 mg daily; 100 mg daily for 3 days may be used as a
�loading dose�
Cost: 10
mg, 30 pills = $430.00; 20 mg, 30 pills = $300.00
Indication:
Treatment of rheumatoid arthritis;
may be useful for treating other rheumatic diseases as well
Side
effects: The most common side effects are diarrhea,
nausea, rash, and reversible thinning of the hair. Elevation
in liver enzymes can occur, and there may be a slight
increased risk of respiratory infection
Monitoring:
Blood count and liver enzymes monthly for the first 3
months, then every 2 months while taking this medication
Important
points to know: Take this medication with food to reduce
gastrointestinal side effects. It should not be used in
patients with chronic liver disease. Influenza (injectable,
not oral) and pneumococcal vaccinations should be considered
if not up to date. This drug is not to be used during
pregnancy! Women who desire to become to become pregnant
should first clear this medication from their body by using a
cholestyramine for 11 days.
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