|
Methotrexate (Rheumatrex)
Available:
Injectable � 20 mg, 25 mg, 50 mg,
100 mg, 250 mg, and 1 gram vials in a 25 mg/mL
preservative-free solution; Oral � 2.5 mg tablets
Dose:
7.5 to 25 mg weekly (may be dosed higher for treating
different conditions); Pediatric dosing 10 mg/m2
Cost:
$28.00 for 16 2.5 mg tablets (generic)
Indications:
Most commonly used for treating
rheumatoid arthritis or psoriatic arthritis, but may also be
used for treating lupus or other inflammatory diseases
Side
effects: Nausea, diarrhea, mouth sores, sore throat,
reversible thinning of the hair, suppression of blood counts,
elevation of liver enzymes rarely leading to liver damage,
increased susceptibility to infection, and rare lung damage
Monitoring:
Blood count, liver and kidney function studies should be
performed at baseline and then every 1 to 2 months while on
therapy. Hepatitis testing may also be ordered prior to
starting therapy per the discretion of your provider. A
baseline chest x-ray may be needed if not done with the past
year prior to starting therapy.
Important
points to know: Contact your provider if any possible
side effects occur. Take tablets on a full stomach to reduce
nausea. Wear protective clothing or sunscreens to reduce sun
sensitive reactions. Avoid or minimize alcoholic beverages,
which can further increase the chance of liver damage while
taking this medication. Report any increased difficulty
breathing or any infectious illnesses to your health care
provider. Methotrexate is not for use during pregnancy or
while breast feeding. Despite the above side effects,
methotrexate has actually been shown to improve survival in
rheumatoid arthritis patients in addition to reducing joint
damage. Most side effects can be prevented or minimized with
proper monitoring.
|
