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Mycophenolate
Mofetil (Cellcept)
Available: 250 mg
and 500 mg capsules or tablets
Dose: 500 mg daily
to 2 grams twice daily depending on the patient�s weight, age,
and the condition being treated
Cost: 250 mg, 100
tablets = $277.17; 500 mg, 100 tablets = $550.18
Indications:
Treating moderate to severe complications of lupus or
vasculitis; may be useful in other rheumatic diseases as well
Side effects:
Nausea, vomiting, and diarrhea are the most common side
effects. Rash, headache, tremor, or difficulty sleeping are
less frequently reported. Anemia or a decrease in white blood
cells or platelets may also occur. Liver enzymes may become
elevated; less commonly, potassium or phosphorus levels may
decrease, and blood glucose or cholesterol levels may increase
while taking this drug. While generally less of a problem
than with other immunosuppressive drugs, patients are more
susceptible to infection when taking this medication.
Monitoring: Blood
counts and liver enzymes should be done monthly initially,
then every 1-3 months once the patient is on a stable dose of
the medication.
Important points to know:
Capsules should not be crushed or opened. To
improve absorption, this medication should be taken on an
empty stomach. Antacids should particularly be avoided
for 1 hour before or 2 hours after taking this drug. Many
other medications (Questran, Zovirax, Imuran, Theophylline,
Dilantin, Benemid, and aspirin, e.g.) may also interfere with
mycophenolate mofetil. Sunscreens should be utilized, and
prolonged exposure to sunlight should be avoided. For women,
birth control should be practiced while taking this medication
and for 6 weeks after it is discontinued. It should also not
be given to mothers who are breastfeeding.
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